Company Profile
Helix BioPharma Corp. a clinical-stage biopharmaceutical company developing therapies in the field of immune-oncology in Canada. Its product pipeline comprises L-DOS47, a clinical-stage antibody-enzyme conjugate (AEC) that neutralizes the microenvironment of solid tumors.
Its portfolio also includes LDOS001, which is in phase I clinical trial to treat non-small cell lung cancer, LDOS002, which is in phase I/II clinical trial for the treatment of non-small cell lung cancer, LDOS003, which is in phase II clinical trial to treat non-small cell lung cancer, LDOS006, which is in phase Ib/II for the treatment of pancreatic cancer, and LDOS007, which is in phase Ib/II for the treatment of lung cancer.
It develops V-DOS47, an antibody-DOS47 conjugate that targets the vascular endothelial growth factor 2 receptor. It has collaboration agreements with Moffitt Cancer Center to investigate the pharmacodynamics of L-DOS47 and determine the benefits of combining L-DOS47 with immune checkpoint inhibitors
With University Hospital Tuebingen to assess the therapeutic response of L-DOS47 in cancer models expressing CEACAM6, with advanced preclinical metabolic imaging. The company has an agreement with metaShape Pharma AG for covering LEUMUNA, within the field of adipose tissue-related and metabolic diseases. Incorporated in 2008, Helix BioPharma is headquartered in Vancouver, Canada.